Physiological activity and receptor binding of 9α fluorohydrocortisone

Abstract

Hepatic gluconeogenic stimulation by 9αfluorocortisol was associated with saturation of GR 1 and GR 3 entities of the glucocorticoid specific receptor (GR), even in presence of spironolactone; renal glycogen levels were not altered. Binding to MR 1 and MR 2 components of the mineralocorticoid specific receptor (MR) in the kidney persisted even in presence of 100 fold excess of nonradioactive corticosterone although this was totally abolished by cold equimolar spironolactone. These data suggest that this fluorinated derivative may be particularly appropriate in studying organ specific responses.