Abstract
Pathogenic effects associated with Helicobacter pylori infection include peptic ulcer. Eradication of H. pylori by triple therapy often results in emerging resistance of H. pylori. Thus there is a need to seek alternative treatments. The aim of this study was to estimate abscisic acid (ABA) isolated from honey of Black Locust (Robinia pseudoacacia) in Korea. The anti-H. pylori activity of ABA was the minimun inhibitory concentrations (MIC), minimum bactericidal concentration (MBC), and postantibiotic effect (PAE). The MIC and MBC of ABA were 2.7±1.3μg/ml and 6.9±1.3μg/ml, respectively. The PAE of ABA was highest at 32×MIC concentrations for 8.5 hr. We determined that ABA may be the potential lead phytochemical constituents with anti-H. pylori activity. The acacia honey in Korea could be useful chemopreventive agents for peptic ulcer in H. pylori-infected individuals
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