Abstract
Thrombin-induced thromboxane (TX) A 2 production in whole blood, as reflected by serum TXB 2 measurements, has proven to be a simple and reproducible capacity-related index of platelet TXA 2 production ex vivo . In the present study we have determined the influence of a number of physiologic variables on serum TXB 2 measurements performed by radioimmunoassay in a group of 177 subjects undergoing evaluation for atherosclerosis risk factors. Serum TXB 2 averaged 300±108 ng/ml in the whole group, with a normal distribution. No statistically significant correlation was found between serum TXB 2 and the continuous variables examined (age, BMI, blood pressure, cigarettes, serum cholesterol, triglyceride, glucose and wine consumption) except for the number of platelets. Platelet TXB 2 production did not differ between men and women (296±119 vs 302±100 ng/ml). We conclude that, within the limits of the examined variables, serum TXB 2 is an easily measurable and highly reproducible capacity index primarily related to platelet cyclooxygenase and TX-synthase activity, which can be used for monitoring drug- or disease-induced changes of these enzyme activities.
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