Abstract
Therapeutic hypothermia (TH) has been recognized in recent decade since the success of two landmark randomized clinical trials in patients with out-of-hospital cardiac arrest. Moreover, TH has been tried in a myriad of neurologic diseases for various purposes such as 1) for controlling an elevated intracranial pressure in patients with huge ischemic stroke or intracerebral hemorrhage, or 2) for aiming at neuroprotection in acute brain injury. Here, we will briefly review the physiologic changes occurring with TH. Key Words: Therapeutic hypothermia; Mechanism; Neuroprotection; Physiology
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