Physiologic Effects of Leptin, Insulin and Triamcinolon on Adult Male Japanese Quail

M Máčajová,D Lamošová,M Zeman

doi:10.2754/avb200372040515

Abstract

Maaajova M ., D . L amo‰ova, M . Z eman: Physiological Effects of Leptin, Insulin and Triamcinolon on Adult Male Japanese Quail.Acta Vet. Brno 2003, 72: 515-522. The effects of leptin, insulin and triamcinolone on body weight, food intake and some physiological parameters of adult Japanese quail males were investigated in this study. Hormones were administered intramuscularly for 4 days. The birds were weighed and decapitated 24 hours after the last dose. Drug administration did not change the body weight of quail. The weight of testes decreased and the weight of liver increased ( P < 0.001) after administration of triamcinolone. Food intake in animals treated with leptin and insulin did not change, but after triamcinolone administration higher food consumption (P < 0.01) was recorded. The activity of alkaline phosphatase in plasma was significantly higher in triamcinolone ( P < 0.001) treated group compared to control. After triamcinolone administration the amount of proteins in muscle decreased ( P < 0.05). Concentration of leptin in plasma among groups did not differ. The most considerable changes were observed after triamcinolone injection, especially in glucose and lipid metabolism.

Highlights

The effects of leptin, insulin and triamcinolone on body weight, food intake and some physiological parameters of adult Japanese quail males were investigated in this study
The body weight of Japanese quail did not change after treatment with leptin, insulin and triamcinolone (Fig. 1A)
Application of leptin and insulin did not influence the amount of cholesterol in plasma, but triamcinolone significantly (P < 0.001) increased its level (Fig.2D)

Summary

Introduction

The effects of leptin, insulin and triamcinolone on body weight, food intake and some physiological parameters of adult Japanese quail males were investigated in this study. Food intake in animals treated with leptin and insulin did not change, but after triamcinolone administration higher food consumption (P < 0.01) was recorded. Leptin is important in the regulation of food intake and energy balance, but it appears increasingly as a general metabolic hormone involved in many physiological processes including inhibition of insulin secretion from β-cells of the pancreas (Fehmann et al 1997), stimulation of glucose utilization (Kamohara et al 1997), stimulation of lipolysis in adipocytes (Frühbeck et al 1997) and increasing of fatty acids synthesis in liver (Cohen et al 1998). With reduced leptin levels, amount of corticosterone in plasma was increased (Ahima et al 1998)

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