Abstract
AbstractThe alteration in pharmacologic action attending the introduction of a keto group into the side chain of oxyphenbutazone to form keto‐oxyphenbutazone (G‐29701) include loss of antirheumatic and sodium retaining properties of the parent compound and appearance of uricosuric action correlated with the much greater acidity of the molecule (pKa 2.3). Comparison with sulfinpyrazone (Anturan) or zoxazolamine (Flexin) shows G‐29701 to have a comparable unicosuric potency witb a significantly longer half life of 8 hours.
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