Abstract
The physiologic disposition and metabolic fate of 1-(p-chlorobenzoyl)-5-dimethylamino-2-methylindole-3-acetic acid, an analog of indomethacin, were studied in several animal species and in man. This compound was well absorbed after oral administration and widely distributed in tissues. The drug was extensively metabolized in all species by hydrolysis of the p-chlorobenzoyl substituent, which was excreted in the urine as p-chlorobenzoyl-glycine. In this respect, the title compound differed from indomethacin in that the latter did not undergo hydrolysis in the dog. The acyl glucuronide was a metabolite of both drugs in man.
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