Abstract
I T has long been thought that normal physiologic mechanisms might be involved in the development of pathologic changes. In an endocrine tissue like the thyroid in which tumors have developed, such a relationship appears to exist. Much data have been collected which demonstrate similarities between normal and neoplastic thyroid tissue. With the establishment of these physiologic mechanisms in thyroid tumor development and maintenance, a basis for a rational form of management has been developed. A consideration of these relationships in the genesis and management of thyroid tumors is the purpose of the present paper.
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