Physiochemical Properties of Benzophenone and Curcumin-conjugated PAMAM Dendrimers Using Topological Indices

Abstract

Curcumin longa (Turmeric) contains an extremely strong phytochemical called curcumin, which has various medicinal and industrial benefits, including anti-inflammatory and anti-cancer effects, textile dyeing, and food and beverage colorants. However, due to its poor bioavailability and low aqueous solubility, it is unstable. These physiochemical properties limit curcumin’s clinical application. In order to solve this problem, scientists recently made new PAMAM dendrimers of the zero, first, and second generations conjugated with curcumin and benzophenone, which is a water-soluble secondary metabolite. Here, we use topological indices to examine these novel PAMAM dendrimers. Adriatic indices, which are a subclass of topological indices, can be used to measure how the arrangement of atoms in a chemical structure affects its most important physical properties. In this study, the parameters of the aforementioned dendrimer, including its density, retention duration, enthalpy, and lipophilicity, are calculated and analyzed based on 16 distinct adriatic indices. Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for the treatment of human diseases.