Abstract
This paper describes the physiochemical, optical and biological activity of chitosan-chromone derivative. The chitosan-chromone derivative gels were prepared by reacting chitosan with chromone-3-carbaldehyde, followed by solvent exchange, filtration and drying by evaporation. The identity of Schiff base was confirmed by UV-Vis absorption spectroscopy and Fourier-transform infrared (FTIR) spectroscopy. The chitosan-chromone derivative was evaluated by X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), photoluminescence (PL) and circular dichroism (CD). The CD spectrum showed the chitosan-chromone derivative had a secondary helical structure. Microbiological screening results demonstrated the chitosan-chromone derivative had antimicrobial activity against Escherichia coli bacteria. The chitosan-chromone derivative did not have any adverse effect on the cellular proliferation of mouse embryonic fibroblasts (MEF) and did not lead to cellular toxicity in MEFs. These results suggest that the chitosan-chromone derivative gels may open a new perspective in biomedical applications.
Highlights
Chitosan is an abundant heteropolysaccharide obtained from deacetylation of chitin, which is a polysaccharide of natural origin and second most abundant to cellulose
The preparation of chitosan-chromone derivative is shown in Scheme 1
UV-Vis and Fourier-transform infrared (FTIR) spectroscopy were used to confirm the structure of the Schiff base of chitosan
Summary
Chitosan is an abundant heteropolysaccharide obtained from deacetylation of chitin, which is a polysaccharide of natural origin and second most abundant to cellulose. Sci. 2012, 13 researchers lies in the biocompatible, biodegradable, cytocompatible, hemocompatible and adsorption properties of chitosan, which can be exploited to create unique building blocks with novel function via Schiff base [1,2,3,4] These properties are attracting interest for use in pharmaceutical and biomedical fields, including as antimicrobials, gene delivery, carriers of immobilized enzymes and cells, biosensors, artificial organs, and biodegradable packaging, as well as wound healing and as scaffolds for tissue regeneration [5,6,7,8,9,10,11,12,13,14,15,16]. The heteropolysaccharide backbone of chitosan is structurally similar to glycosaminoglycans, the major component of the extracellular matrix of the bone [20]
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