Physiochemical investigation of the excipients mixed micelles for improvement of encapsulation and controlled release of antihistamine drugs

Abstract

Today's biotechnology and pharmaceutical industries significantly depend on amphiphilic excipients due to their enhanced drug-binding characteristics for delivery systems. This study emphasizes the significance of pharmaceutical excipients that could produce mixed micelles to enhance drug delivery systems. Tartrazine (TAZ) and cetyltrimethylammonium bromide (CTAB) mixed micellization were stabilized using surface tension, conductivity, and steady-state fluorescence quenching techniques. Using the Levenberg-Maquardt least squares technique, the CMC values derived from the conductivity experimental data were also taken into account. Clint's, Rubingh's, and Motumura's approaches were used to investigate the characteristics of mixed micelles to comprehend the effectiveness of TAZ-CTAB mixtures. The TAZ-CTAB-mixed micelles were shown to have a more potent synergistic interaction. The binding constant (LogKb), mean ion occupancy (i0), and encapsulation efficiency (% EE) of the antihistamines cetirizine hydrochloride (CTZ) and chlorpheniramine maleate (CPM) was enhanced by raising the TAZ from αTAZ 0.1 to 0.9999. In addition, the controlled release of CTZ and CPM in PBS at pH 7.4 was around 50 % in mixed micelles after 50 h at αTAZ 0.7 to 0.9. In summary, the dyes and surfactants might be utilized in a mole fraction ratio to improve the binding properties of active medicinal ingredients while concurrently lowering the quantity of excipients needed in pharmaceutical formulations.