Abstract

Schiff base ligand and its Cu(II) complex had been synthesized by the condensation reaction of isatin with amino acids (cysteine / glycine / leucine / alanine ). The Structure and spectral properties of ligand and complex were confirmed by UV, FT-IR and some physiochemical measurements. The spectral properties showed that it was a distorted tetrahedral geometry with a tridentate ligand and chloride ion. IR spectral studies show the binding sites of the Schiff base ligand with the metal ion. Molar conductance data and magnetic susceptibility measurements give evidence for monomeric and non-electrolytic nature of the complexes. The Schiff base Cu(II) complex was subjected to antimicrobial studies screened by employing the Disc Diffusion method. All the synthesized complexes showed strong antibacterial activity.

Highlights

  • Multidentate ligands are extensively used for the preparation of metal complexes with interesting properties [13]

  • Schiff bases obtained by the condensation of Isatin and amino acids in presence of potassium hydroxide find application as antituberculosis compounds

  • In view of our interest in synthesis of new Schiff base complexes, which might find application as pharmacological and as luminescence probes, we have synthesized and characterized Cu(II) metal ion complexes of noble Schiff base formed by the condensation of isatin and amino acids in presence of potassium hydroxide

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Summary

Introduction

Multidentate ligands are extensively used for the preparation of metal complexes with interesting properties [13]. Schiff bases obtained by the condensation of Isatin and amino acids in presence of potassium hydroxide find application as antituberculosis compounds. They find application in the biophysical and clinical studies as metal ligand luminescence probes [8]. In view of our interest in synthesis of new Schiff base complexes, which might find application as pharmacological and as luminescence probes, we have synthesized and characterized Cu(II) metal ion complexes of noble Schiff base formed by the condensation of isatin and amino acids in presence of potassium hydroxide

Experimental
Synthesis of Schiff Bases
Synthesis of Metal Complexes
Physical Measurement
IR Spectral Analysis
Characterizations by UV-Visible Spectra
Conclusion
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