Abstract
The drug jadwar known as Delphinium denudatum Wall (Ranunculales: Ranunculaceae), the jadwar consist of dried tuberous roots of D. denudatum. An annual glabrous or slightly downy herbs found is Western Himalayas from Kumaon to Kashmir at altitudes of 3,000 m to 4,500 m specially on grassy slopes. It is distinguished by its relatively small blue and violet color and it is one of the important drugs used as indigenous medicine in India, especially in where isolated from the petroleum ether-soluble fraction of roots of D. denudatum. Jadwar widely used in traditional unani system of medicine for the treatment of a variety of human ailments including epilepsy. In order to increase the bioavailability, the nanophytosome of the D. denudatum root aqueous fraction (DNP) was prepared, characterized and evaluation. The phospholipids complex of the obtain aqueous fraction (AF) was prepared with phospholipon 90H. The size of nanophytosome was determined by dynamic light scattering. HPTLC fingerprinting of the AF was also performed.
Highlights
The generic name Delphinium of jadwar is derived from a Greek word, which means dolphin
The purity of the isolated compound was analyzed by thin layer chromatography
The present study is an attempt to ascertain the pharmacopoeial standard for the standardization of the D. denudatum sample the purity, quality, identity and strength of the powder has been undertaken as a tool to bring out several features like ash standards, solubility in alcohol and water, successive extraction values, and qualitative screening of physicochemical studies (Anonymous, 1952; India, 2010; Rahman et al 1997)
Summary
Rhizome (root) of D. denudatum (Tamil-Nirbasi) was purchased from Khari Baoli Market, Old Delhi, India. Sagheer Ahmed, R&D Head of Department Hamdard Laboratory Ghaziabad. Preparation of crude extract of D. denudatum rhizome. The root sample (D. denudatumrhizome) was washed well and shadedried. Rhizome were chopped into small pieces and grounded to a fine powder by using grinder mixer. The solvent petroleum ether was used for the crude extracts preparation. The powered root material was packed in the filter paper and placed gently in the soxhlet apparatus. The extraction was carried out for 14-16 cycles at 50 °C. The crude extract obtained was further concentrated by using rotary evaporator and used for the further studies
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