Abstract
The interaction between ciprofloxacin and β-cyclodextrin leading to the formation of an inclusion complex was studied by phase-solubility, UV, X-ray diffractometry, differential scanning, calorimetry differential thermal analysis, infra red and NMR spectroscopy. Partial inclusion of the drug moiety within the β-cyclodextrin cavity along with an interaction of the carbonyl function of the carboxylic acid of ciprofloxacin with the hydroxyl function of β-cyclodextrin leaving the piperazine moiety hanging around the narrower rim of the cyclodextrin cavity was established. Change in the crystallinity coupled with improved stability of the drug was also observed on complexation. For improved stability, the complex may be used in place of the drug alone.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
