Abstract
The interaction between ciprofloxacin and β-cyclodextrin leading to the formation of an inclusion complex was studied by phase-solubility, UV, X-ray diffractometry, differential scanning, calorimetry differential thermal analysis, infra red and NMR spectroscopy. Partial inclusion of the drug moiety within the β-cyclodextrin cavity along with an interaction of the carbonyl function of the carboxylic acid of ciprofloxacin with the hydroxyl function of β-cyclodextrin leaving the piperazine moiety hanging around the narrower rim of the cyclodextrin cavity was established. Change in the crystallinity coupled with improved stability of the drug was also observed on complexation. For improved stability, the complex may be used in place of the drug alone.
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