Abstract
The interaction of gold(III) trichlorophenanthridine complex, [Au(phend)Cl3], with calf thymus DNA was investigated by UV–Vis absorption, circular dichroism, and fluorescence spectrophotometery as well as viscometry, cyclic voltammetry (CV), and molecular docking. The values of binding constants K b (obtained by UV–Vis) and K f (obtained by fluorescence) are 3 × 104 and 7.68 × 105 M−1, respectively. Evidence for intercalation comprised a hyperchromic effect at 210 nm and a hypochromic effect at 250 nm caused by the ligand, increasing the T m of DNA, increasing of viscosity, increasing the intensity of the positive peak, decreasing the intensity of the negative peak, and the positive shift of the cathodic peak potential in CV.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
