Abstract

Binding Effect of Cassava Starches on the Compression and Mechanical Properties of Ibuprofen TabletsJudith Chitedze, Maurice Monjerezi, JD Kalenga Saka, Jan Steenkamp

Highlights

  • Cassava (Manihot esculenta) is a perennial tuber plant widely grown in many tropical countries including Nigeria as one of the most important commercial crops

  • Starch is an important excipient employed in the pharmaceutical industry but irrespective of its source, the native starch is undesirable for many applications because of its inability to withstand processing conditions and the need for it modification in order to improve its desired properties

  • The granular morphology, amylose and amylopectin fractions, ash value, true density, powder porosity, swelling capacity, hydration capacity, moisture sorption capacity, bulk density, tapped density, Carr’s index, Hausner’s ratio, angle of repose, X-ray diffractography, elemental and proximate analysis were used for the physicochemical characterizations and was subsequently compared with native Manihot esculentum starch

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Summary

Introduction

Cassava (Manihot esculenta) is a perennial tuber plant widely grown in many tropical countries including Nigeria as one of the most important commercial crops. Cassava is second only to sweet potato as the most important starchy root crop of the tropics (Grace, 1977). Irrespective of their source, are undesirable for many applications (Wang et al, 1993) because of their inability to withstand processing conditions such as extreme temperature, diverse pH, high shear rate and freezethaw variation. Temperature and moisture contents during processing of starch alter its functional properties. The molecular interactions (hydrogen bonding between starch chains) after cooling of the gelatinized starch paste have been called retrogradation (Hoover, 2001).

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