Abstract
Herbal medicines often contain bioactive polysaccharides. However, many medicinal herbs have not been explored for any active saccharides that may play key roles in their bioactivities. Herein, we extracted a novel polysaccharide from Mirabilis himalaica (Edgew) heim (denoted MHHP), a popular medicinal ingredient in traditional medicines. The structural and morphological characteristics of MHHP were measured and elucidated by high-performance gel permeation chromatography, gas chromatography connected with mass spectrometry, Fourier transform infrared and nuclear magnetic resonance spectroscopy as well as scanning electron microscopy. MHHP was homogeneous with a molecular weight of 16.1 kDa, Mw/Mn = 1.33, containing mainly α-d-glucan residues with (1→4)-linkage. The biological activities of MHHP upon proliferation of splenic lymphocyte, activation of related cytokine and production of nitric oxide (NO) in RAW264.7 cells were investigated in vitro. MHHP induced proliferation of mouse spleen lymphocytes and significantly promoted the secretion in TNF-α, IL-6 and NO production in RAW264.7 cells. Meanwhile, MHHP exhibited relatively low antioxidant abilities. Our data suggested that MHHP may have potential immunoregulatory and anti-inflammatory activity, with a moderate antioxidant activity.
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