Abstract
Zinc-substituted fluorohydroxyapatite/beta-tricalcium phosphate (ZFHA/β-TCP) nanocrystals were prepared by a novel solid-state synthesis method. From Rietveld refinement of XRD patterns, no phase transformations and secondary phases were detected, and single-phase Zn2+-doped FA was observed as dopant concentration increased. A significant increase in crystallite sizes was observed after heat treatment at 900 °C. Spheroidal nanoparticles with an average particle size of 44.0 ± 6.4 nm and a narrow particle size distribution were detected by electron microscopy. 98% and 100% reductions in the number of colonies were observed for ZFHA/β-TCP against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), respectively. A typical apatite layer was developed on the surface of the substituted structure even after 3 days of immersion in simulated body fluid (SBF).
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