Abstract
In a biological system, the airway system upper respiratory tract, or trachea connects the nostrils and lungs, to help in breathing process and trapping dust and pathogen particles. Clinically, to overcome the tracheal defects and dsyfunctioning different type of artificial prosthetics, stents, and grafts are used to reconstruct tracheal tissue at the injured tissue. Decellularized tissue fabricated from xenogeneic and allogeneic tissue are Extracellular matrix (ECM) protein rich, biocompatible, 3D biomimetic grafts having potential mechanical stability for better tissue regeneration. Acellular tracheal graft fabricated from the cadaver goat-tracheal tissue have 3D interconnected porous structure with good mechanical stability upto 18 MPa measured by UTM, stability and control degradability rate. Biochemical analysis by the FTIR spectra analysis and assays confirmed the presence of stable collagenous protein triple helix structure with retained majority of the ECM (extra cellular matrix) molecules (collagen, proteoglycans, elastin and GAGs) without any significant loss, bio-degradability, and physiochemical stability.
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