Abstract
International Journal of Pharmacology and Clinical Sciences,2015,4,3,44-47.DOI:10.5530/ijpcs.4.3.2Published:Sept 2015Type:Original ArticleAuthors:Mekala, Sathish, and Arul Amuthan Author(s) affiliations:Mekala1, Sathish2, Arul Amuthan3* 1Department of Nanju Noolum Maruthuva Neethi Noolum, National Institute of Siddha, Chennai, INDIA. 2Department of Sattam Saarntha Maruthuvamum Nanju Noolum, Sri Sairam Siddha Medical College, Chennai, INDIA. 3Department of Pharmacology, Melaka Manipal Medical College and Center for Integrative Medicine and Research, Manipal University, INDIA. Abstract:Background: Pavalasilasathu parpam (PSP) is one of the marine derived drugs used in Siddha Medicine for the treatment of leucoderma and respiratory infections. So far, no studies have been done on this drug. Objective: To prepare pavalasilasathu parpam as per the traditional Siddha literature and to evaluate its chemical changes during drug preparation processes. Materials and Methods: First, Suddhi (purification) process of pavalam (coral) and silasathu (selenite) were done by individually processed with Aloe vera juice and tender coconut water respectively. The chemical change in coral and selenite before and after the purification process was analyzed using Fourier transform infrared spectroscopy (FTIR) and inductively coupled plasma optical emission spectroscopy (ICP-OES). Then, coral and selenite were ground well together with Cissus quadrangularis juice for 12 hours and subjected to calcination process. The obtained whitish ash was called as PSP. The physico-chemical property of PSP was analyzed using ash values, FTIR, ICP-OES and Scanning Electron Microscope (SEM). Amount of heavy metal was quantified. Results: The procedure Suddhi reduced the amount of sodium, iron, calcium, phosphorous, sulfur and magnesium in coral and selenite. Particle size ranges between 30-80 μm. Heavy metals like mercury, lead, arsenic and cadmium were below detectable level. Amount of calcium, phosphorous and sulphur were 225 mg, 10 mg and 22 mg in 1 g of PSP. FTIR showed the peaks for the presence of six organic compounds. Conclusion: Pavalasilasathu parpam does not have heavy metals, but contains calcium, phosphorous and Sulphur with few organic phytochemicals derived from Cissus quadrangularis, which was used during the preparation process. Keywords:Ayurveda, Bhasma, Cissus Quadrangularis, Corel, Leucoderma, Marine, Pavalam, Selenite, SiddhaView:PDF (643.88 KB) PDFClick here to download the PDF file. Images Scanning electron microscope (SEM) picture of pavalasilasathu parpam
Highlights
Siddha Medicine, one of the oldest Indian traditional medicines describes variety of marine derived drugs including fishes, shells, sponges and corals
Pavalasilasathu parpam (PSP) is one of such marine based Siddha drug mainly used in the treatment of leucoderma, diabetes mellitus, certain infectious conditions such as tuberculosis, respiratory infections, syphilis and venereal infections
FT-IR showed that there was no change in the organic functional groups of coral even after the purification process (Aloe vera treatment)
Summary
Siddha Medicine, one of the oldest Indian traditional medicines describes variety of marine derived drugs including fishes, shells, sponges and corals. Pavalasilasathu parpam (PSP) is one of such marine based Siddha drug mainly used in the treatment of leucoderma, diabetes mellitus, certain infectious conditions such as tuberculosis, respiratory infections, syphilis and venereal infections. Pavalam (coral), silasathu (selenite), Aloe vera, Cissus quadrangularis and tender coconut water are the five ingredients in this preparation.[1] Usually, preparation of mineral based Siddha drugs is a lengthy procedure and believed that the Mekala et al.: Physico-chemical evaluation of pavalasilasathu parpam combinatorial and transmutation changes occur during the processing. Conclusion: Pavalasilasathu parpam does not have heavy metals, but contains calcium, phosphorous and Sulphur with few organic phytochemicals derived from Cissus quadrangularis, which was used during the preparation process
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