Abstract
Naproxen solid dispersions were prepared by melting and rapid cooling with liquid nitrogen using lactose as a carrier. The physical characterisitics of these solid dispersions were investigated by powder X-ray diffraction, differential scanning calorimetry and dissolution rate analyses. The degree of crystallinity of naproxen in solid dispersions decreased with decreases in the molar ratio of naproxen to lactose. Fourier-transform infrared (FT-IR) analysis demonstrated the presence of intermolecular hydrogen bonds between naproxen and lactose in solid dispersions. Dissolution studies indicated that the dissolution rate was markedly increased in solid dispersions compared with physical mixtures and pure drugs. These results indicated that lactose is useful as a carrier for production of solid dispersions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.