Abstract
In the present work, a phytocomplex formed by ethanol extract of Bryophyllum pinnatum (Lam.) Oken (EEBP) and β-cyclodextrin (βCD) has been prepared at weight proportion of 1:1, characterized through several physical chemistry methods, and incorporated in an oil-in-water emulsion in order to evaluate its topical anti-inflammatory effect. Changes in the spectra of infrared and UV/VIS as well as TGA and DTA curves suggested the existence of interactions between components of extract and βCD. The incorporation of βCD to the extract also promoted an increase in the zeta potential of the aggregates spontaneously formed in water, with consequent reduction of their size. The in vitro antioxidant activity was also evaluated, showing an improvement of the radical-scavenging ability in presence of βCD. Finally, the topical application of EEBP/βCD semi-solid formulation significantly inhibited the ear edema induced by Croton oil if compared with free EEBP, justifying the use of phytotherapic formulation based on B. pinnatum as a remedy for skin disorders.
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