Abstract
Objective: The objective of this study was standardization and Chemical characterization of rasamanikya prepared as per standard operating procedures (SOP) mentioned in the classical text.
 Methods: Rasamanikya was prepared by putting churnodaka shodhita haratala (Orpiment-As2S3) between two abhraka (white mica) sheets which are heated for a while to obtain a red colored finished product. The Ayurvedic specifications for the analysis of rasamanikya were performed through qualitative and quantitative analysis. Physicochemical analysis, assay of elements by atomic absorption spectrometer (AAS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES) were carried out and some other tests such as x-ray diffraction (XRD), x-ray photoelectron spectroscopy (XPS) and energy dispersive x-ray analyzer (EDAX) were also performed to ensure the quality of the drug.
 Results: In the finished drug Arsenic and Sulphur are present in the form of As4S4, As2S3, As2S5. On the basis of XPS survey scans, scanning electron microscopy-energy dispersive x-ray analyzer (SEM-EDAX) and carbon, hydrogen, nitrogen, sulphur (CHNS) analysis the Arsenic to Sulphur (As to S) ratio is thus standardized as 39-47: 53-61. In addition to this powder, XRD shows a major conversion into an amorphous phase.
 Conclusion: The results could be used to lay down a new set of pharmacopoeial standards for the preparation of rasamanikya for getting optimal efficacy of medicine. Therefore, the information will help the Scientists and Researchers to build comprehensive standards, to screen the compounds responsible for different bioactivities, and to elucidate the molecular mechanism of action.
Highlights
Rasamanikya is a well known ayurvedic arsenical preparation, which is prepared out of shuddha haratala
Rasamanikya was prepared by following standard methods mentioned in the Ayurvedic Formulary of India [7]
The Organoleptic observation shows that the prepared rasamanikya is in the form of a yellowish fine powder having no characteristic odour and taste
Summary
Rasamanikya is a well known ayurvedic arsenical preparation, which is prepared out of shuddha haratala. The formulation has been first described in Rasendra Chintamani in the 13th century A. D. as Rasam manikya prabham [1]. The same product has been described in Siddha Bheshaja Manimala as kumuda rasa [2]. Tala manikya is one of the synonyms of rasamani kya. It is commonly and effectively used in various kustha roga (skin diseases), shwasa (Bronchial asthma), vicharchika (Eczema), bhaganadara (Fistula), vatarakta (Gout), phiranga roga (Syphilis), jwara (Fevers), kasa (Cough), and nadi vrana (Chronic wounds) with different anupanas in various dosage forms [3, 4]
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