Physicochemical assessment of an orabase formulation of <em>Libidibia ferrea</em> L

Abstract

The aim of the study was to control the physicochemical quality of an orabase formulation of L. ferrea L. An experimental, in vitro, controlled study was carried out as follows: centrifuge tests, pH, density, rheological behavior at room temperature (25.0 ± 2.0 °C), microbiological control by determining the total number of aerobic microorganisms, yeast growth, and organoleptic characteristics. The storage conditions were as follows: light room (±25.9°C), dark room (±28.8°C), refrigerator (± 2 to 8°C), and the experimental periods were 0, 30 and 60 days. In the centrifuge test, the separation of 1 oily phase (liquid and transparent) was observed in all storage conditions and times tested; in the pH test, the formulation remained stable with pH variations between 6.01 and 6.67, but there was no statistically significant difference at all times and conditions tested. The rheological behavior in terms of viscosity revealed that time and storage conditions did not alter the samples and the mean standard values related to rotation were 6 mPa.SNa (5111.9 ±11), 12 mPa.S (2555.2 ±7), 30 mPa.S (1023.9 ±2) and 60 mPa.S (512.5 ±4). The assessment of contaminants revealed no growth of contaminants in the storage conditions and times tested. As for the organoleptic characteristics, the samples showed no changes throughout the time and storage conditions. The formulation is physically and chemically stable under all storage conditions and times tested, proving to be suitable for extemporaneous formulations.