Abstract
To analyze and compare several commercially available acrylic intraocular lenses (IOLs) with particular regard to their clinical significance, we examined the physicochemical and surface properties of four currently available acrylic IOLs using static water contact angle, atomic force microscopy (AFM), Raman spectroscopy, and differential scanning calorimetry (DSC) measurements. The hydrophobic acrylic IOLs, ZA9003, and MA60BM, had contact angles ranging from 77.9° ± 0.65° to 84.4° ± 0.09°. The contact angles in the hydrophilic acrylic (970C) and heparin-surface-modified (HSM) hydrophilic acrylic IOLs (BioVue) were 61.8° ± 0.45° and 69.7° ± 0.76°, respectively. The roughness of the IOL optic surface differed depending on the type of IOL (p < 0.001). The surface roughness of BioVue had the lowest value: 5.87 ± 1.26 nm. This suggests that the BioVue IOL may lead to reduced cellular adhesion compared to the unmodified IOLs. All IOLs including those composed of acrylic optic materials from different manufacturers showed distinct Raman spectra peaks. The glass transition temperatures (Tg) for the hydrophobic acrylic IOLs were between 12.5 and 13.8 °C. These results suggest that the intraoperative and postoperative behavior of an IOL can be predicted. This information is also expected to contribute greatly to the industrial production of reliable biocompatible IOLs.
Highlights
A cataract is a clouding of the lens in the eye and normally occurs as part of the aging process
We examine the physicochemical and surface properties of four currently available acrylic intraocular lenses (IOLs) using static water contact angle, atomic force microscopy (AFM), Raman spectroscopy, and differential scanning calorimetry (DSC) measurements
The contact angle was measured to evaluate the hydrophilicity of the IOLs, as shown
Summary
A cataract is a clouding of the lens in the eye and normally occurs as part of the aging process. The natural lens of eye is replaced by an artificial lens [intraocular lens (IOL)]. This IOL is placed in the lens capsule (Fig. 1), where it remains after cataract surgery. Some patients may have difficulties with vision again a few months to a few years after cataract surgery. This is not a re-growth of cataract; it is because of the thickening of the back of the lens capsule. PCO results from the growth and abnormal proliferation of lens epithelial cells (LECs) on the posterior capsule. Posterior capsule opacification (PCO) is an issue of concern for most cataract surgeons (Apple et al 2001; Findl et al 2005; Hollick et al 1999; Kohnen et al 2008)
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