Physicochemical and mechanical properties of electrospun polyurethane composite patch integrated with green synthesized cobalt nanoparticles for cardiac applications

Abstract

Cardiac patches are used to recover the damaged cardiac tissues. In this research, cardiac patch was fabricated using electrospinning method and evaluated for its physicochemical properties. The patch was made from polyurethane (PU) added with cobalt nanoparticles (CoNPs) which is synthesized through green route via green tea containing polyphenols. The 0.5 mg/mL, 1.0 mg/mL and 1.5 mg/mL cobalt salt concentrations mixed with green tea solution produced different nanoparticles morphology. Further, synthesized CoNPs with cobalt salt concentration of 1.5 mg/mL was incorporated in the PU using electrospinning method. The developed patches with higher CoNPs ratio exhibited smaller diameter compared to PU as observed using SEM. PU- CoNPs patch rendered hydrophilic surface with lower ratio of CoNPs. On the other hand, higher ratio of CoNPs exhibited enhanced strength compared to the pristine PU. Patches with the improved physicochemical properties and mechanical strength can be exploited for cardiac applications.