Abstract
The paper presents a method of modifying the inner surface of nanofibrous vascular prostheses. The modification process involves two steps: introducing a hydrophilic linker, followed by a peptide containing the arginine-glutamic acid-aspartic acid-valine (REDV) sequence. The influence of the process parameters (reaction time, temperature, initiator concentration) on morphology and the distribution of fiber diameters were examined. For selected optimal parameters, the prostheses were modified in the flow system. Modifications along the entire length of the prosthesis were confirmed—the inlet and the outlet areas showed no significant (p > 0.05) differences in the value of the contact angle and the analyzed morphological parameters. The basic physicochemical and mechanical properties of modified prostheses were analyzed. The study showed that REDV-modified prosthesis has an average fiber diameter of 318 ± 99 nm, the average pore size of 3.0 ± 1.6 μm, the porosity of 48.4 ± 8.6% and Young’s modulus of 4.0 ± 0.4 MPa. The internal diameter of prostheses remains unchained and amounts to 3 mm. Such modified prostheses can reduce the risk of blood coagulation by increasing the surface’s wettability and, most of all, by introducing endothelial cell-selective peptide. As an effect, the proposed surfaces could recruit endothelial progenitor cells directly from the bloodstream and promote the endothelium formation after implantation.
Highlights
The presented work focuses on the process of surface modification of cylindrical nanofibrous scaffolds that can be used as vascular prostheses
Carboxyl groups present on acrylic acid (AA)-grafted PU are activated with sulfo-NHS/EDC
A modification process that enables introducing a peptide to the internal surface of cylindrical nanofibers prostheses is proposed
Summary
The presented work focuses on the process of surface modification of cylindrical nanofibrous scaffolds that can be used as vascular prostheses. There is a great demand for small-diameter vascular prostheses that can be used as bypasses in the treatment of coronary artery disease [1]. Small diameter prostheses must meet several requirements but above all, they must be characterized by high hemocompatibility [2]. The formation of even a small clot can lead to blockage of the prosthesis’ lumen. It is important to ensure the high hemocompatibility of the internal surfaces. Various techniques have been proposed to increase the hemocompatibility of the material
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