Abstract
Physicochemical and Biopharmaceutical Characterization of N-Iodomethyl-N,N-Dimethyl-N-(6,6-1 Diphenylhex-5-En-1-Yl) Ammonium Iodide and A Promising Antileishmania Delivery System
Highlights
Current drug therapies for cutaneous leishmaniasis (CL) are unsatisfactory due to numerous drawbacks including severe side effects, reproductive toxicity, prolonged treatment with high doses and decreased effectiveness
One of the objectives pursued for the treatment of leishmaniasis is the development of more effective and safer active pharmaceutical ingredients that can be administered topical or orally to ensure greater acceptance by patients
Our study continued with the pharmacological characterization; the C6I exhibited low dissolution profile with a IDR value similar in the three different pH, the Differential scanning calorimetry (DSC) and DRX analysis confirmed that C6I presented a crystalline structure, as described by others authors [7,8]
Summary
Current drug therapies for cutaneous leishmaniasis (CL) are unsatisfactory due to numerous drawbacks including severe side effects, reproductive toxicity, prolonged treatment with high doses and decreased effectiveness. Advantaged communities, new drugs development lack for economic incentives to large pharmaceutical companies and in consequence, leishmaniasis is designated as neglected tropical disease [1,2]. Other physiochemical studies showed that the solubility of C6I is high in acetonitrile (1.5 mg/mL), low in methanol, isopropanol and chloroform (< 1.0 mg/mL) and water (0.61 mg/mL). This solubility is not affected by pH changes [5]
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