Abstract
The potentiometric and conductometric titration methods have been used to characterize the stability of series of VO(IV)-, Co(II)- and Ni(II)-oxydiacetato complexes in DMSO-water solutions containing 0–50 % (v/v) DMSO. The influence of DMSO as a co-solvent on the stability of the complexes as well as the oxydiacetic acid was evaluated. Furthermore, the reactivity of the complexes towards superoxide free radicals was assessed by employing the nitro blue tetrazolium (NBT) assay. The biological properties of the complexes were investigated in relation to their cytoprotective activity against the oxidative damage generated exogenously by using hydrogen peroxide in the Human Dermal Fibroblasts adult (HDFa) cell line as well as to their antimicrobial activity against the bacteria (Bacillus subtilis, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis). The relationship between physicochemical and biological properties of the complexes was discussed.
Highlights
Polycarboxylate metal complexes have attracted the interest of many research teams because of their extensive applications in wide areas from material to biological sciences [1,2,3,4,5,6,7]
We report a study on cytoprotective properties of [VO(ODA)(H2O)2], [Co(ODA)(H2O)2]·H2O and [Ni(ODA)(H2O)3]·1.5H2O against the oxidative damage generated exogenously in the Human Dermal Fibroblasts adult (HDFa) cell line as well as their antimicrobial activities against the bacteria (Bacillus subtilis, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis)
It has been found that the stability constants of the cobalt(II) and nickel(II) complexes are equal in the range of experimental error but for the oxovanadium(VI) complex, the stability constant is ca. 1 order higher (Table 2)
Summary
Polycarboxylate metal complexes have attracted the interest of many research teams because of their extensive applications in wide areas from material to biological sciences [1,2,3,4,5,6,7]. The oxydiacetate ion belongs to dicarboxylate ligands, and it contains the ethereal donor atom that is capable to take part in the coordination to the central atom. The flexibility of this ligand enables to adopt, depending on the kind of metal ion and a method of synthesis, different geometrical conformations from a planar (mer coordination) to folded about the M-O vector (fac coordination) [11, 12]. Several metal complexes comprising oxydiacetate as a primary ligand and α-diimine as an auxiliary ligand, [M(ODA)(bipy)(H2O)]∙xH2O [M=Cu2+ or Ni2+, x=4; Cr2+, x=3; Co2+, x=2] and [VO(ODA)(bipy)]∙2H2O as well as [M(ODA)(4-pic)(H2O)]∙xH2O [M=Cu2+ or Ni2+, x=2; Cr2+, x=3; Co2+, x=4] and [Fe(ODA)(4-pic)]Cl, have been found to exhibit antibacterial activities [14, 15]
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