Abstract

This study was to investigate the physicochemical and biological activities of sea cucumber polysaccharides extracted from waste residue of peptide production (SCRP). The monosaccharide composition of SCRP was 20.03% mannose, 19.56% glucose, 18.63% galactose, 25.94% arabinose and 15.82% fucose with the Mw and Mn of SCRP of 57.5 and 51.3 kDa. The intrinsic viscosity of SCRP was 8.9 mL/mg with a liquid-like rheological behaviour. Two main endothermic peak temperatures of the SCRP sample were 85.03 and 231.80°C. SCRP rendered the early apoptosis of cells, as well as induced the loss of mitochondrial transmembrane potential and increase the reactive oxygen species (ROS) level with a concentration-dependence manner. The results implied that a by-product SCRP could be extracted from the waste residue during peptide production, and exhibited inhibitory effects against MDA-MB-231 cells.

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