Abstract
Caffeine, a widely used stimulant is a purine based xanthine alkaloid which can lead to mutagenic effects in DNA helix via pairing errors. In order to study the interactions between caffeine and the pyrimidine based model compounds of nucleic acids, densities ρ, viscosities η, and enthalpies of dilution, q of aqueous solutions of some nucleic acid bases and nucleosides have been determined at different concentrations of caffeine over a temperatures range (288.15–318.15) K. Apparent molar volumes at infinite dilution (Vo2,ϕ), viscosity B-coefficient (B), and standard molar enthalpy of dilution (∆dilHo), and the corresponding transfer parameters at infinite dilution have also been calculated. The nature of solute–co-solute interactions is exothermic. UV–visible and NMR spectroscopic studies have been carried out and the shifts in absorption spectra and NMR spectra signify the role of hydrophobic interactions. An effort has been made to compare the present work with the similar properties in other co-solutes.
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