Physico-chemical characterisation of glycerol- and ethylene glycol-based deep eutectic solvents

Abstract

Deep eutectic solvents are of significant interest to numerous applications including cryopreservation, chemical synthesis, lubrication, energy storage, catalysis, and self-assembly. However, to date there have been few rigorous and systematic studies of the physico-chemical and thermal properties of these solvents. This means that conclusive structure-function relationships are difficult to define within the context of the current literature. Here, we present the viscosity, refractive index, density, surface tension, and thermal behaviour of mixtures of either glycerol or ethylene glycol with choline chloride, betaine, or L-proline, as neat fluids and in the presence of water. We demonstrate that changing the ratio of hydrogen bond donor to hydrogen bond acceptor has only a small effect on the physico-chemical properties, while the addition of even small quantities of water has a significant effect. Despite rigorous studies, we demonstrate that determining the eutectic point of these mixtures is not straight-forward and that the definition of a ‘deep’ eutectic solvent may need to be reviewed in the frame of ideal mixing theory.