Abstract
One of the premises for physician-patient interaction is primum non nocere (first, do no harm), and this principle has been recently discussed regarding the use of drug samples.1,2 There have also been ethical challenges to sample use in our literature, and anecdotal reports of adverse irritant reactions to misuse of samples.3,4 In therapeutic decisions, the risk-benefit should be considered for each patient and treatment. In dermatology, this is particularly important in the choice of topical therapy or recommendations of over-the-counter products for abnormal skin, because the active ingredient (corticosteroid), the vehicle, or other ingredients could sting, burn, irritate, orsensitize.
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