Abstract
BackgroundAltered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents of the lipid metabolism process. We investigated the effect of physical resistance training on lipid metabolism and apoptosis in the adult Wistar rat prostate.MethodsTwo experimental groups represented sedentary and physical resistance training. Three days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a physical resistance exercise protocol. Two days after the last training session, rats were anesthetized and sacrificed for blood and prostate analysis.ResultsPhysical exercise improved feeding efficiency, decreased weight gain, regulated the serum-lipid profile, and modulated insulin-like growth factor-1 (IGF-1) and free testosterone concentration. Furthermore, upregulation of cluster of differentiation 36 (CD36), sterol regulatory element binding protein-1 (SREBP-1), sterol regulatory element-binding protein cleavage-activating protein (SCAP), and reduced lysosome membrane protein (LIMPII) expression were also observed in the blood and prostates of trained rats. Consistent with these results, caspase-3 expression was upregulating and the BCL-2/Bax index ratio was decreased in trained rats relative to sedentary animals.ConclusionsIn this work, physical resistance training can alter lipid metabolism and increase markers of apoptosis in the prostate, suggesting physical resistance training as a potential novel therapeutic strategy for treating prostate cancer.
Highlights
Prostatic diseases are the most common male malignancy worldwide and therapeutic approaches aim to increase prostate cancer cell apoptosis and reduce proliferation to prevent lesion progression
Altered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents of this lipid metabolism process, and physical exercise has been shown to increase the
Bodyweight, status of food consumption, and biochemical parameters To determine the impacts of physical exercise on parameters of prostatic health, we subjected adult Wistar rats to either a sedentary lifestyle or physical resistance training for 13 weeks
Summary
Prostatic diseases are the most common male malignancy worldwide and therapeutic approaches aim to increase prostate cancer cell apoptosis and reduce proliferation to prevent lesion progression. Altered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents of this lipid metabolism process, and physical exercise has been shown to increase the Previous studies conducted in our laboratory have shown that strength or resistance training affects the prostate by promoting hormonal changes and cell turnover [6,7,8]. Considering that cholesterol is an essential requirement for cell growth and proliferation, it has been implicated in several different type of cancers, notably within prostate tumors [11] It is unclear how changes in circulating lipid and anabolic hormones levels induced by long-term resistance training may affect prostate health, proliferation, and apoptosis. We investigated the effect of physical resistance training on lipid metabolism and apoptosis in the adult Wistar rat prostate
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