Abstract
Preserved ratio impaired spirometry (PRISm) is associated with an increased mortality rate; however, its characteristics have not been clearly identified in Japan. This cross-sectional study of community-dwelling older adults compared physical function between people with PRISm and those with no respiratory issues, from 2014 to 2019. We collected demographic data through interviews and measured respiratory and physical functions. We included 668 older adults (male, 23.5%; mean age, 72.8 ± 5.6 years); the prevalence of PRISm was 12%, while the prevalence of obstruction was 6.9%. Propensity score matching was used to identify control subjects with normal spirometry (n = 80) while minimizing the effects of confounders during comparisons with the PRISm population (n = 80). Compared with community-dwelling older adults with normal lung capacity, older adults with PRISm had a lower forced vital capacity (%FVC; 68.7 ± 9.1% vs. 92.5 ± 12.7%, p < 0.001), lower core muscle endurance (sit-up test: 6.7 ± 5.8 vs. 8.7 ± 6.0, p = 0.032), and a longer one-leg stance duration (52.4 ± 41.1 s vs. 36.4 ± 34.1 s, p = 0.008). In multivariable logistic regression, %FVC and increased one-leg stance were independent predictors of PRISm status. The prevalence of PRISm among community-dwelling elderly Japanese exceeds that of obstructive lung disease and is associated with reduced %FVC and better performance on balance testing.
Highlights
The Genetic Epidemiology of chronic obstructive pulmonary disease (COPD) (COPDGene) study and other reports discussing P RISm1–3,8,18 have explained the condition using medical data[4,6,9]
Past research has reported the prevalence of chronic obstructive pulmonary disease (COPD) in communitydwelling persons[19,20], as well as physical function and cognitive function characteristics of community-dwelling individuals suspected of having COPD21–25
Previous studies have found that individuals with Preserved ratio impaired spirometry (PRISm) have a shorter 6-min walk distance; we hypothesised that PRISm would be associated with a decline in physical function, such as reduced limb skeletal muscle strength and flexibility
Summary
The Genetic Epidemiology of COPD (COPDGene) study and other reports discussing P RISm1–3,8,18 have explained the condition using medical data[4,6,9]. Past research has reported the prevalence of chronic obstructive pulmonary disease (COPD) in communitydwelling persons[19,20], as well as physical function and cognitive function characteristics of community-dwelling individuals suspected of having COPD21–25. Previous studies have found that individuals with PRISm have a shorter 6-min walk distance; we hypothesised that PRISm would be associated with a decline in physical function, such as reduced limb skeletal muscle strength and flexibility. Poorer physical function than individuals with normal respiratory function, it would be possible to use physical function parameters and physical characteristics as early warning signs of PRISm. in this study, we aimed to clarify the prevalence of hidden PRISm in Japan and to investigate differences in terms of attributes and physical function between community-dwelling older adults with normal respiratory function and those with PRISm
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