Abstract
The objective of this study was to investigate the application of the physically modified rice starch (MRS) produced by alcoholic-alkaline (MRS-AA) and planetary ball-milling (MRS-BM) methods as an ODF film former. Rice starch was isolated from Thai rice grain. XRD and ATR-FTIR results confirmed crystallinity loss of MRS. MRS-AA exhibited prominently the greater swelling capacity, whereas MRS-BM exhibited prominently the greater cold water solubility. The starch-based orodispersible films (ODFs) with acceptable film and mechanical properties were successfully prepared using solvent casting method. MRS-based ODFs exhibited the greater flexible behaviors but lower disintegration time compared with the native system. Desloratadine loaded MRS-BM-based ODFs disintegrated within 62.3 ± 23.1 s, with more than 95% dissolution within 10 min. In conclusion, the ball-milling treatment resulted in the preferable MRS suitable for use as an ODF film former. This study therefore provides a glimpse into the use of physically modified starch as an ODF film former.
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