Physical interactions between induced electrical fields can have substantial effects on neuronal excitation during simultaneous TMS of two brain areas

Abstract

Objective To analyse the interactions between simultaneous or nearly simultaneous focal transcranial magnetic stimulation (TMS) of the motor cortex hand area (M1 hand) of both hemispheres. Methods In 7 healthy subjects, motor evoked potential (MEP) amplitude and cortical silent period (CSP) duration were elicited in the right hand by bihemispheric focal TMS of M1 hand (8-shaped coils, monophasic current waveform, stimulus intensity 120% above motor threshold, TMS of right M1 hand preceding TMS of left M1 hand by 0–1000 μs), or by unilateral TMS of left M1 hand alone. A dipole probe was used to measure the physical interactions between the two stimulating coils. Results Bihemispheric TMS markedly decreased MEP and CSP at intervals of 0 and 50 μs compared to unilateral TMS, whereas both measures increased at the interval of 150 μs. The dipole probe experiments showed that the physical interactions between the electrical fields of the two coils entirely explained the MEP and CSP findings, but only under the assumption that excitation of M1 hand is not point-focal but extends over several centimetres. Conclusions First, simultaneous focal TMS of distant brain sites may result in marked ‘distortion’ of brain excitation through physical interaction between the induced electrical fields. Second, these findings support the notion that excitation of human M1 hand is relatively non-focal, even if a ‘focal’ stimulating coil and low stimulus intensity are used. Significance Potentially marked physical interaction between induced electrical fields must be taken into account when testing or disrupting distant brain sites with simultaneous focal TMS.