Abstract
Physical influences on stem cells
Highlights
We invited some of the leaders of the burgeoning field of physical regulation of stem cells to critically review biophysical regulation of stem cell fate and function in the context of tissue development and regeneration
Stem cells respond to the entire context of their environment, and physical signals play major roles throughout development and adult life
Our muscles and joints develop under rather dynamic mechanical conditions, and their well-being throughout development and adult life critically depends on physical regulatory signals
Summary
We invited some of the leaders of the burgeoning field of physical regulation of stem cells to critically review biophysical regulation of stem cell fate and function in the context of tissue development and regeneration. Whereas the regulatory roles of morphogens have been extensively studied, physical signals are much less defined while being important for most of our tissues. Our muscles and joints develop under rather dynamic mechanical conditions, and their well-being throughout development and adult life critically depends on physical regulatory signals.
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