Abstract
Objectiveto assess the impact of longitudinal change of the overweight and physical activity on hyperuricemia.MethodsWe performed a retrospective cohort study. Demographic information, clinical features, laboratory findings, body weight and physical exercises pattern were documented.ResultsAltogether 4678 cases of hyperuricemia were enrolled. The median aged males were most affected. Individuals in the middle age had the highest prevalence of being overweight (2501/3382, 74.0%). Middle aged with BMI≥25 kg/m2 were more likely to lose weight (963/2807, 34.3%). BMI and waist circumference control helped to reduce serum uric acid. Overweight population was more likely to use urate-lowering or uricosuric medication (3025/3382, 89.4%). Intermediate and heavy activity were associated with bigger SUA improvement. Patients in the age of 35-60 were more likely to do physical exercises than the others.ConclusionBeing overweight is strongly associated with hyperuricemia. Successful weight control was correlated with significant uric acid reduction. Intermediate to heavy physical activity helps to reduce waist circumference and SUA. In the hyperuricemia population, obese, middle aged men were the most affected, and also the most likely to do more exercises and get their bodyweight back to normal.
Highlights
High levels of serum uric acid (UA) has been rapidly increasing in the general population [1, 2]
Being overweight is strongly associated with hyperuricemia
Successful weight control was correlated with significant uric acid reduction
Summary
High levels of serum uric acid (UA) has been rapidly increasing in the general population [1, 2]. Accumulating clinical evidence suggests that hyperuricemia is associated with various metabolic disorders [3]. Similar prevalence has been found in China [4]. There are studies indicating that being overweight might be related with different metabolic burden [5]. Obesity [body mass index (BMI) ≥30 kg/m2] and central adiposity [waist circumference (WC) ≥80 cm women (WCF), ≥90 cm men (WCM)] are prodromal conditions for metabolic syndrome (MetS) [6, 7]. Previous study showed that intensive physical exercises may prevent athletes from developing metabolic syndrome (MetS). Some reports suggested that physically active lifestyle would help to improve cardiometabolic disorders. Some reports suggested that physically active lifestyle would help to improve cardiometabolic disorders. [9, 10]
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