Physical Characterization of Nanoemulgel containing Ethanol Extract of Curcuma mangga Val. using Carbopol 940 as Gelling agent

Abstract

Curcuma mangga Val. is one of the plants which traditionally has been known to have many pharmacological activities. The aim of this study was to develop a topical nanoemulgel dosage form using Curcuma mangga Val. ethanol extract. The preparation was started with the nanoemulsion formulation using Tween 80 as surfactant, also ethanol and propylene glycol as co-surfactant. Castor oil and MCT oil were used as the oil phase and Carbopol 940(0.5 and 1.5%) were used as gelling agent to produce nanoemulgel. The organoleptic test, pH determination, type of emulsion, homogeneity test, viscosity, particle size distribution of the nanoemulgel were evaluated to determine the nanoemulgel physical characterization. The accelerated stability test was conducted by centrifugation, heating cooling and shaking tests for the nanoemulgel. The result showed that the Curcuma mangga Val. ethanol extract was successfully loaded in the nanoemulgel formulation with pH 5.38-5.77, showed oil in water emulsion type, homogenous, viscosity in the range of 19.73–31.80 cps and particle size distribution below than 50 nm. The nanoemulgels demonstrated stable condition after accelerated stability test and storage at room temperature for 1 month. It is concluded that Curcuma mangga Val. ethanol extract was appropriate to be formulated in nanoemulgel as topical dosage form.