Abstract
Intact liposome-based targeted nanoparticle delivery systems (NDS) are immobilized bynon-selective binding and characterized by scanning probe microscopy (SPM) in a fluidimaging environment. The size, size distribution, functionality, and stability of an NDSwith a payload consisting of a super-paramagnetic iron oxide contrast agent formagnetic resonance imaging are determined. SPM results are combined withinformation obtained by more familiar techniques such as superconducting quantuminterference device (SQUID) magnetometry, dynamic light scattering, and electronmicroscopy. By integrating the methods presented in this work into the NDSformulation and manufacturing process, size-dependent statistical properties of thecomplex can be obtained and the structure–function relationship of individual,multi-component nanoscale entities can be assessed in a reliable and reproduciblemanner.
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