Physical Characterization and Dissolution Study of Pentagamavunon-0 Loaded Self Nano-Emulsifying Drug Delivery System

Ika Yuni Astuti,Agung Endro Nugroho,Marchaban Marchaban,Ronny Martien

doi:10.14499/indonesianjpharm29iss2pp60

Abstract

The recent work focuses on the physical characterization and dissolution study of PGV-0 loaded self-nanoemulsifying drug delivery system (SNEDDS). The PGV-0 SNEDDS was prepared by spontaneous emulsification method using oleic acid, tween 20:labrasol (1:1) and polyethylene glycol 400. The zeta potential of the PGV-0 SNEDDS was -34.4 ± 7.66 mv. The nanoemulsion of PGV-0 SNEDDS was thermodynamically stable with forming droplet oil containing PGV-0 in it and spherical. The dissolution result showed that the PGV-0 SNEDDS was able to increase the dissolution significantly (p <0.05) compared with PGV-0 powder of 44.13% in AGF medium and 30.37% in AIF medium. It is concluded that SNEDDS PGV-0 was able to increase the PGV-0 aqueous solubility.

Highlights

Administration of an antiinflammatory agent is very commonly used for a variety of inflammatory conditions and diseases
One hundred PGV-0 self-nanoemulsifying drug delivery system (SNEDDS) was added to 100 mL distilled water, artificial intestinal fluid (AIF), and artificial gastric fluid (AGF) respectively
ANOVA statistic analysis followed by Least Significant Difference (LSD) test on C45 parameter using SPSS program at 95% confidence level indicated that the C45 of PGV-0 SNEDDS in both AGF (78%) and AIF (73%) were significantly higher than PGV0 powder in AGF (2.22%) and AIF (1.65%) (Table I)

Summary

INTRODUCTION

Administration of an antiinflammatory agent is very commonly used for a variety of inflammatory conditions and diseases. According to Wahyuningsih, the apparent permeability constant (Papp) value of PGV-0 obtained from the in situ absorption test is 1.91x 10-4cm/sec (Wahyuningsih, 2003), which means that PGV-0 has a high permeability (>10-5 cm/sec) It has a high permeability value, so it is absorbed orally, but its bioavailability is low. To improve the dissolution of PGV-0, a novel formulation technology called self nanoemulsifying drug delivery system (SNEDDS) was applied to PGV-0. In this regard, PGV-0 is dissolved in a nano-sized droplet of oil in the gastrointestinal tract so that the interface area in contact with gastrointestinal fluid and membranes is increased. The characteristics of SNEDDS was assessed for the morphological and droplet size, the zeta potential and the physical stability of the nanoemulsion

MATERIALS AND METHODS

RESULT

PGV-0 powder in AGF

Evaluation and Research December