Abstract
IntroductionMidlife physical capability (PC) is associated with developmental factors in the populations of economically developed countries. As far as we know, there is no information for rural populations of low- and middle-income countries. The aim of the study was to investigate the influence of pre- and postnatal factors on midlife objective measures of PC in a 1966–67 birth cohort from a Mexican rural community. The hypothesis was that adverse developmental conditions are associated with low midlife PC.MethodsIn 1966–67, a birth cohort of all children from a poor Mexican rural community was assembled. Data on family socioeconomic status (SES), parental health and nutritional status, birth weight, postnatal growth and feeding patterns were registered. In 2018, out of the 336 cohort members, 118 were living in the community, and eighty-two of them underwent a comprehensive clinical evaluation. The evaluation included grip strength, gait velocity and chair-stand PC tests. In multivariable linear models, PC tests were the dependent variables, and prenatal, birth and postnatal factors were the independent variables. Adjustment for confounding was made with adult anthropometric, body composition, clinical and ageing status variables.ResultsIndependent of adult health status and other ageing indicators, lower PC was associated with family organization and SES, parental nutritional status, birth weight, infant postnatal growth velocity, and weaning time. These results indicate that adverse family and environmental conditions that are prevalent in poor rural communities are associated with low midlife PC.
Highlights
Midlife physical capability (PC) is associated with developmental factors in the populations of eco‐ nomically developed countries
Independent of adult health status and other ageing indicators, lower PC was associated with family organi‐ zation and socioeconomic status (SES), parental nutritional status, birth weight, infant postnatal growth velocity, and weaning time
These results indicate that adverse family and environmental conditions that are prevalent in poor rural communities are associated with low midlife PC
Summary
Midlife physical capability (PC) is associated with developmental factors in the populations of eco‐ nomically developed countries. One of the main identified factors is maternal undernutrition [1] This association has been explained by the concept of "developmental programming by early-life. Arroyo et al BMC Geriatrics (2022) 22:113 undernutrition" [2] The evidence of this relationship comes from studies of populations exposed to prenatal famine episodes and adult health outcomes [3, 4]. Poor rural communities of low-income and middle-income countries present a different nutritional epidemiological pattern characterized by chronic protein energy maternal and infant undernutrition [5]. Longstanding cohort studies in these types of communities have confirmed the association of maternal and child undernutrition with adult outcomes such as height, education level, income level, birth weight of offspring, BMI, glucose concentration, and blood pressure [6]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
