Abstract
Denture stomatitis and fungal infection are commonly found in long-time denture wearer. Ionic liquids have been used as plasticizer and also possess antimicrobial activity. In this study, ionic liquid in form of 1-Decyl-3-methy-limidazolium chloride was incorporated into tissue conditioner (GC Soft-liner TM) to improve antifungal activity. Physical and mechanical properties were evaluated. Compliance was carried out using penetration test according to ISO 10139-1. Weight change, water absorption and solubility were determined by weight measurement. Conventional and nystatin-incorporated tissue conditioner served as controls. Results showed that ionic liquid-incorporated tissue conditioner significantly decreased fungal formation, both in material suspension and on material surface. The penetration depth of all groups tended to reduce over time with no significant difference at each time point. After water immersion, ionic liquid- and nystatin-incorporated tissue conditioner gained weight while conventional group showed weight loss. The percentage of water absorption of conventional group was significantly lower than ionic liquid and nystatin group, while the percentage of water solubility of nystatin group was significantly higher than others. Our work indicated that antifungal ionic liquid-incorporated tissue conditioner met the standard criteria in terms of material compliance. However, further studies including dynamic viscoelastic property are needed before clinical trial or application.
Highlights
One of the main problems occurring in long-term denture wearers is the deposition of plaque on tissue surface of the denture, especially in elderly or disabled person who cannot achieve good oral hygiene
The percentage of water absorption of conventional group was significantly lower than ionic liquid and nystatin group, while the percentage of water solubility of nystatin group was significantly higher than others
The antifungal activity was evaluated by examining the percentage of log colony forming unit (% colony-forming unit (CFU)) of C. albicans in suspension and on materials
Summary
One of the main problems occurring in long-term denture wearers is the deposition of plaque on tissue surface of the denture, especially in elderly or disabled person who cannot achieve good oral hygiene. This problem often leads to the infection and inflammation of underneath mucous membrane. The first choice of denture stomatitis treatment is to remove denture in order that oral tissue can recover into normal condition, along with antifungal drug prescription if the sign of fungal infection is presented [6] [7]. The deposited plaque is difficult to be removed by mechanical or chemical method, as it would cause a distortion of denture liner. Surface roughness and porosity of denture liner itself increase the amount of deposited microorganisms
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