Abstract
Growing interest in silicone elastomers for pharmaceutical purposes is due to both their beneficial material effect for scar treatment and their potential as drug carriers. Regarding their morphological structure, silicone polymers possess unique properties, which enable a wide range of applicability possibilities. The present study focused on developing a double-layer adhesive silicone film (DLASil) by evaluating its physical and mechanical properties, morphology, and stability. DLASil suitability for treatment of scars and keloids was evaluated by measurement of tensile strength, elasticity modulus, and elongation. The results indicated that mechanical and physical properties of the developed product were satisfying.
Highlights
Usage of silicone polymers for pharmaceutical purposes has dynamically increased over the last few years
The graph shows the physical structure of double-layer adhesive silicone film (DLASil) and parameters that were determined in order to assess applicability and physical structure of DLASil and parameters that were determined in order to assess applicability stability of DLASil as dermal patches
It is proposed as a general strategy to characterise the adhesive and stability of DLASil as dermal patches
Summary
Usage of silicone polymers for pharmaceutical purposes has dynamically increased over the last few years. Both medical devices and dosage forms are being developed. Silicone materials can be found as excipients mostly in preparations for external use, such as gels, creams, patches, films, or dressings [1]. For treatment of scars and keloids the most popular approach, indicated in clinical recommendations [2,3], is the use of a silicone patch without active substances, since its beneficial influence on scars results from the material’s unique properties [4,5,6]. Proper physical and mechanical parameters of the material are crucial to achieve the therapeutic effect
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