Abstract
A review of previous work indicates that the mathematical modelling of adsorption rate processes is well established and provides a basis for predictive methods for scale-up. Small-scale experiments to provide isotherm and kinetic data for code prediction purposes are described and pilot-scale equipment to provide results for code predictions are outlined. Predictions of the performance of a packed-bed adsorption column using numerical methods incorporated in the FACSIMILE code show good agreement with results from an analytic solution, and with the experimental data of Chase for affinity adsorption of lysozyme on Blue Sepharose CL-6B. This is part of a programme aimed at validating the FACSIMILE code for application to the design, performance prediction, optimization and scale-up of industrial adsorption and chromatography equipment.
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