Abstract
The mangosteen peels (Garcinia mangostana L.) has high free radical scavengers activity. This study aims to determine the physical and chemical conditions that are formulated in SNEDDS and nanoemulsion preparations. SNEDDS was made with various concentrations of Tween 80, PEG 400, and Virgin Coconut Oil (VCO) with a ratio of 4,98:1,02:1. Nanoemulsions were made with the addition of water to SNEDDS. Stability observation results were analyzed by statistics. The results of physical stability test show that all test samples in the research, in nanoemulsion, SNEDDS fraction, base SNEDDS, SNEDDS vitamin E did not undergo separation, precipitation, cracking, and creaming. On the chemical stability test of nanoemulsion and SNEDDS fraction there is no difference between IC50 before and after storage. While on basic SNEDDS and vitamin E nanoemulsion there is a difference between IC50 before and after storage.
Highlights
The mangosteen peels (Garcinia mangostana L.) has high free radical scavengers activity
This study aims to determine the physical and chemical conditions that are formulated in SNEDDS and nanoemulsion preparations
Mixed surfactant based (SNEDDS) selfnanoemulsifying drug delivery system presenting efavirenz for enhancement of oral bioavailability
Summary
Penelitian ini menggunakan desain penelitian eksperimental untuk mengetahui stabilitas sediaan nanoemulsi dan SNEDDS. Bahan utama yang digunakan dalam penelitian ini adalah kulit manggis yang diperoleh dari Kaligesing, Kecamatan Purworejo, Provinsi Jawa Tengah. DPPH (Sigma Aldrich), metanol (Merck), etil asetat (Merck), Tween 80 (Bratachem), PEG 400 (Bratachem), etanol 70% (Dwicentra), nheksan (Merck), akuades (Dwicentra), VCO (Bagoes). Ekstraksi Sampel Sebanyak 5 kg kulit buah manggis diekstraksi dengan maserasi selama 72jam menggunakan etanol 70%. Sampel kemudian diuapkan dengan waterbath sampai menjadi ekstrak kental. Fraksi etil asetat kulit manggis Ekstrak etanol 70% kental difraksinasi dengan n-heksan untuk mendapatkan fraksi nheksan dan bagian yang tidak larut n-heksan. Bagian yang tidak larut dalam n-heksan ditambahkan dengan pelarut etil asetat untuk mendapatkan fraksi etil asetat. Selanjutnya fraksi etil asetat dikumpulkan dan dipekatkan dengan waterbath pada 40±0,5°C untuk mendapatkan fraksi etil asetat
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