Abstract
Following a preliminary review of pertinent literature citations, a total of 84 semisolid, water-soluble, anhydrous bases for possible ophthalmic use was formulated. Of these 84 exploratory bases, five were designated evaluatory bases for further study on the basis of apparent pH and/or desirable physical spread- ability characteristics over the temperature range of 0-50°. Four of the five bases were further characterized by rotational viscometer studies, and an organogel was selected on the basis of several of its listed attributes as the best attempt in this investigation to formulate the type of semisolid base desired for possible ophthalmic use.
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