Abstract
Dehydro-thermal treatments for 3, 24 and 72 h were used to crosslink blends of collagen and poly(vinyl alcohol) with various compositions. This crosslinking method increases the biological stabilityin vitro of collagen, as was established by an enzymatic test. When the poly(vinyl alcohol) content is not more than 20% the resistance of collagen to enzymatic digestion is not affected by the presence of the synthetic component. A higher content of poly(vinyl alcohol) produces a steric hindrance screening that enhances the resistance of collagen to the collagenase. Dehydro-thermal treatment performed for 24 and 72 h increases the crystallinity of poly(vinyl alcohol), thus reducing the solubility of this component of the blend. Calorimetric analysis was carried out by differential scanning calorimetry to investigate the structure and the thermal stability of the blends. Dehydro-thermal treatments carried out for 24 and 72 h induce high degrees of crosslinking in collagen and high crystallinity in poly(vinyl alcohol). The two components of the blend seem to create independent structures and the blend can show interpenetrating-network-like behaviour.
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